Avatrombopag Maleate- Thrombocytopenia, CAS No.: 677007-74-8

Kev piav qhia

Cov khoom xyaw nquag hauv AVATROMBOPAG MALEATE yog avatrombopag maleate, thrombopoietin receptor agonist. Lub npe tshuaj ntawm avatrombopag maleate yog

4 piperidinecarboxylic acid, 1-[3-chloro-5-[[[{4}}(4-chloro-2 thienyl)-5-({ {8}}cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridinyl]-, (2Z)-2-butenedioate (1:1). Nws muaj cov mis mos molecular C29H34Cl2N6O3S2 · C4H4O4. Qhov hnyav molecular yog 765.73.

Cov qauv tsim qauv yog:

Lub aqueous solubility ntawm avatrombopag maleate ntawm ntau qib pH qhia tau hais tias cov tshuaj yeeb dej caw yog insoluble ntawm pH 1 txog 11.

AVATROMBOPAG MALEATE yog muab los ua cov ntsiav tshuaj tso tawm tam sim. Txhua ntsiav tshuaj AVATROMBOPAG MALEATE muaj 20 mg avatrombopag (sib npaug rau 23.6 mg ntawm avatrombopag maleate) thiab cov khoom xyaw hauv qab no: lactose monohydrate, colloidal silicon dioxide, crospovidone, magnesium stearate thiab microcrystalline cellulose. Txheej zaj duab xis:

polyvinyl cawv, talc, polyethylene glycol, titanium dioxide thiab ferric oxide daj.

Mechanism ntawm Action

Avatrombopag yog ib qho kev hais lus bioavailable, me me molecule TPO receptor agonist uas txhawb kev loj hlob thiab kev sib txawv ntawm megakaryocytes los ntawm cov pob txha pob txha progenitor hlwb, uas ua rau muaj ntau ntau ntawm cov platelets. Avatrombopag tsis sib tw nrog TPO rau kev khi rau TPO receptor thiab muaj cov nyhuv ntxiv.

nrog TPO ntawm platelet ntau lawm.

Pharmacodynamics

Platelet teb

AVATROMBOPAG MALEATE tau tswj hwm rau cov neeg mob laus ua rau muaj koob tshuaj- thiab raug cuam tshuam los ntawm kev nce qib hauv platelet suav. Qhov pib ntawm platelet suav nce tau pom nyob rau hauv 3 mus rau 5 hnub ntawm kev pib kho, nrog rau cov nyhuv siab tshaj plaws tom qab 10 mus rau 13 hnub. Tom qab kev kho mob, cov platelet suav tau txo qis, rov qab mus rau qhov chaw nyob ze

tus nqi.

Lub npe:Avatrombopag txiv neej

Avatrombopag maleate yog ib hom tshuaj siv los kho cov tsos mob ntawm Thrombocytopenia (tsis muaj platelets hauv cov ntshav).

Cov lus qhia

Kev kho mob thrombocytopenia hauv cov neeg mob uas muaj kab mob siab ntev (CLD)

Avatrombopag maleate yog qhia rau kev kho mob ntawm thrombocytopenia nyob rau hauv cov neeg laus cov neeg mob uas muaj kab mob siab ntev uas tau teem caij mus rau ib tug txheej txheem.

Kev kho mob thrombocytopenia hauv cov neeg mob uas muaj kab mob thrombocytopenia (ITP)

Avatrombopag maleate yog qhia rau kev kho mob ntawm thrombocytopenia hauv cov neeg laus cov neeg mob uas muaj lub cev tiv thaiv kab mob thrombocytopenia uas muaj cov lus teb tsis txaus rau kev kho mob yav dhau los.

Hangzhou Jiuyuan yog lub tuam txhab sab saum toj-biotech koom ua lag luam tshwj xeeb hauv kev tshawb fawb, kev tsim kho, tsim khoom, thiab kev lag luam ntawm cov tshuaj raws li cov noob qoob loo thiab kev siv tshuab biochemical txij li xyoo 1993. Nws muaj gene engineering rhiav, kev cob qhia kev txhaj tshuaj, kev cob qhia kws tshuaj API, thiab lwm ntu suav nrog Kev tswj xyuas zoo, lub tsev khaws khoom, chav haujlwm engineering, thiab lwm yam, tag nrho cov no tau tsim ua raws li GMP cov cai. Jiuyuan tau nruab nrog cov cuab yeej tsim khoom thiab tshuaj ntsuam xyuas zoo li chromatography systems, HPLC, thiab capillary electrophoresis. Peb muab cov khoom lag luam zoo thiab cov kev pabcuam muag khoom, thov hu rau peb.

Manufacturing thiab Quality

Ua raws li lub tswv yim ntawm "zoo los ntawm kev tsim", cov qauv kev ua tau zoo yog siab dua li cov kev cai sab nraud.

Ua raws li cov kev cai tshiab GMP, coj los siv los ntawm EU GMP thiab US FDA cov qauv los tsim kev cob qhia ntau lawm.

Qhia txawv teb chaws cov cuab yeej siv siab heev rau cov txheej txheem tseem ceeb.

Cov kab ntau lawm ntawm JILIFEN formulated bulk tau dhau EU GMP ntawv pov thawj.

Lub tuam txhab Honour

National Tshiab High-tech Enterprise

Key Tshiab High-tech Enterprise ntawm National Torch Plan

National superior enterprise ntawm kev txawj ntse cuab yeej

Provincial Tshiab High-tech Research & Development Center

Zhejiang Provincial Enterprise Technology Center

Zhejiang Famous Trademark

Zhejiang Jiuyuan Gene Engineering Biopharmaceutical Research Institute

Cim npe nrov: avatrombopag maleate- thrombocytopenia, cas no .: 677007-74-8, Tuam Tshoj avatrombopag maleate- thrombocytopenia, cas no.: 677007-74-8 manufacturers, lwm tus neeg, Hoobkas