Semaglutide Injection- Diabetes (recombinant Route), poob phaus / mob ntshav qab zib ntau ntau thiab Pre-filled Pen 5ml: 0.25mg, CAS No.: 910463-68-2

Kev piav qhia

SEMAGLUTIDE txhaj, rau kev siv subcutaneous, muaj semaglutide, tib neeg GLP-1 receptor agonist (los yog GLP-1 analog). Lub pob txha peptide yog tsim los ntawm cov poov xab fermentation. Lub ntsiab protraction mechanism ntawm semaglutide yog albumin binding, yooj yim los ntawm kev hloov kho ntawm txoj hauj lwm 26 lysine nrog ib tug hydrophilic spacer thiab ib tug C18 fatty di-acid. Tsis tas li ntawd, semaglutide tau hloov kho nyob rau hauv txoj hauj lwm 8 los muab stabilization tiv thaiv degradation los ntawm enzyme dipeptidyl-peptidase 4 (DPP-4). Ib qho kev hloov kho me me tau ua nyob rau hauv txoj hauj lwm 34 los xyuas kom meej qhov txuas ntawm ib qho

fatty di-acid. Cov mis mos molecular yog C187H291N45O59 thiab qhov hnyav molecular yog 4113.58 g / mol.

Tus qauv qauv:

SEMAGLUTIDE yog cov tshuaj tsis muaj menyuam, muaj dej, ntshiab, tsis muaj xim. Txhua tus cwj mem ua ntej muaj 1.5 mL lossis 3 mL daws ntawm SEMAGLUTIDE sib npaug rau 2 mg semaglutide, 3 mL daws OZEMPIC® sib npaug rau 4 mg ntawm semaglutide, lossis 3 mL daws ntawm OZEMPIC® sib npaug rau 8 mg ntawm semaglutide. . Txhua 1 mL ntawm SEMAGLUTIDE kua muaj {{10}}}.68 mg, 1.34 mg lossis 2.68 mg ntawm semaglutide thiab cov khoom xyaw hauv qab no: disodium phosphate dihydrate, 1.42 mg; propylene glycol, 14.0 mg; phenol 5.50 mg; thiab dej rau kev txhaj tshuaj. SEMAGLUTIDE muaj pH ntawm kwv yees li 7.4. Hydrochloric acid lossis sodium hydroxide tuaj yeem raug ntxiv los kho pH.

Mechanism ntawm Action

Semaglutide yog ib qho GLP -1 analogue nrog 94 feem pua ​​​​kev sib txuas lus homology rau tib neeg GLP-1. Semaglutide ua raws li GLP-1 receptor agonist uas xaiv khi rau thiab qhib lub GLP-1 receptor, lub hom phiaj rau haiv neeg GLP-1. GLP-1 yog ib qho physiological hormone uas muaj ntau yam ua rau cov piam thaj, kho los ntawm GLP-1 receptors. Lub ntsiab mechanism ntawm protraction uas ua rau ib nrab-lub neej ntawm semaglutide yog albumin binding, uas ua rau txo lub raum clearance thiab tiv thaiv los ntawm metabolic degradation. Tsis tas li ntawd, semaglutide yog stabilized tiv thaiv degradation los ntawm DPP -4 enzyme. Semaglutide txo cov ntshav qabzib los ntawm cov txheej txheem uas nws ua rau cov tshuaj insulin tso tawm thiab txo qis glucagon secretion, ob qho tib si hauv cov piam thaj-dependant. Yog li, thaum ntshav qabzib

siab, insulin secretion yog stimulated, thiab glucagon secretion yog inhibited. Cov txheej txheem ntawm kev txo cov ntshav qabzib kuj tseem cuam tshuam nrog kev ncua me me hauv plab hnyuv tawm thaum ntxov postprandial theem.

Pharmacodynamics

Semaglutide txo qis kev yoo mov thiab postprandial ntshav qabzib thiab txo lub cev hnyav. Txhua qhov kev ntsuam xyuas pharmacodynamic tau ua tiav tom qab 12 lub lis piam ntawm kev kho mob (nrog rau kev nce koob tshuaj) ntawm lub xeev khov kho nrog semaglutide 1 mg. Kev yoo mov thiab Postprandial Glucose Semaglutide txo kev yoo mov thiab postprandial qabzib concentrations. Hauv cov neeg mob uas muaj ntshav qab zib hom 2, kev kho mob nrog semaglutide 1 mg tau ua rau txo qis hauv cov piam thaj hauv cov ntsiab lus ntawm qhov tseeb.

hloov los ntawm cov hauv paus thiab cov txheeb ze txo qis piv rau cov placebo ntawm 29 mg / dL (22 feem pua) rau kev yoo mov qabzib, 74 mg / dL (36 feem pua) rau 2- teev postprandial qabzib, thiab 30 mg / dL (22 feem pua) rau txhais tau tias 24- teev piam thaj concentration. (saib daim duab 1).

Insulin secretion

Ob qho tib si thawj-thiab theem ob-theem kev tso tawm insulin ntau ntxiv hauv cov neeg mob ntshav qab zib hom 2 kho nrog OZEMPIC® piv nrog cov placebo. Glucagon Secretion Semaglutide txo qis kev yoo mov thiab postprandial glucagon concentrations. Hauv cov neeg mob uas muaj ntshav qab zib hom 2, kev kho nrog semaglutide ua rau cov txheeb ze txo qis hauv glucagon piv rau cov placebo, yoog glucagon (8 feem pua), postprandial glucagon teb (14-15%), thiab txhais tau tias 24 teev glucagon concentration (12 feem pua. ). Glucose-dependent insulin thiab glucagon secretion Semaglutide txo qis cov ntshav qabzib ntau hauv cov ntshav los ntawm kev txhawb nqa cov tshuaj insulin secretion thiab txo qis glucagon secretion hauv cov piam thaj-dependant. Nrog semaglutide, qhov txo qis ntawm cov tshuaj insulin hauv cov neeg mob ntshav qab zib hom 2 zoo ib yam li cov neeg noj qab haus huv (saib daim duab 2).

Thaum lub sij hawm induced hypoglycemia, semaglutide tsis tau hloov pauv cov lus teb tswj hwm ntawm kev nce glucagon piv rau cov placebo thiab tsis cuam tshuam qhov txo qis ntawm C-peptide hauv cov neeg mob ntshav qab zib hom 2. plab hnyuv

Semaglutide ua rau ncua sij hawm ntawm lub plab zom mov thaum ntxov, yog li txo tus nqi ntawm cov piam thaj hauv cov hlab ntshav tom qab. Cardiac electrophysiology (QTc) Cov nyhuv ntawm semaglutide ntawm lub plawv repolarization tau sim hauv QTc kev sim. Semaglutide tsis ncua QTc ntu ntawm koob tshuaj txog li 1.5 mg ntawm lub xeev khov kho.

Lub npe:Semaglutide

Semaglutide yog ib hom tshuaj uas siv los kho cov tsos mob ntawm hom 2 mob ntshav qab zib mellitus. Semaglutide tuaj yeem siv ib leeg lossis nrog lwm cov tshuaj.

Noj ntau npaum:Txhaj tshuaj

Specification

5ml: 0}.25mg

Cov lus qhia

SEMAGLUTIDE yog qhia:

Raws li ib qho ntxiv rau kev noj haus thiab kev tawm dag zog los txhim kho glycemic tswj hauv cov neeg laus uas muaj ntshav qab zib hom 2.

Semaglutide los txo cov kev pheej hmoo ntawm cov teeb meem loj ntawm cov hlab plawv (mob plawv, tsis tuag myocardial infarction lossis tsis tuag stroke) rau cov neeg laus uas muaj hom 2 mob ntshav qab zib mellitus thiab tsim cov kab mob plawv.

Jiuyuan Gene ua raws li lub tswv yim ntawm "coj los ntawm genetic engineering thiab pab txhawb rau tib neeg kev noj qab haus huv", bravely innovating thiab nrhiav kev ua tau zoo.

Thaum Lub Kaum Hli 1996, lub tuam txhab tau coj tus thawj coj hauv kev tsim kho hauv tsev ntawm cov ntshav dawb-txhawb cov tshuaj tshwj xeeb-Jilifen (rhG-CSF) thiab paub txog nws txoj kev lag luam, rhuav tshem cov kev lag luam ntawm Asmeskas thiab Nyij Pooj thiab yeej lub koob npe nrov ntawm "Tuam Tshoj's. thawj txhaj".

Rau ntau tshaj 20 xyoo, Jiuyuan Gene tau ua tiav pib Ji Lifen, Ji Pai Lin, Ji Jufen, Yi Zhe Jia, Ji Ou Ting thiab Pob Txha Youdao series khoom.

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Cim npe nrov: Kev txhaj tshuaj semaglutide- ntshav qab zib (recombinant route), poob phaus / ntshav qab zib ntau ntau thiab pre-filled cwj mem 5ml: 0.25mg, cas no.: 910463-68-2, Tuam Tshoj semaglutide txhaj- ntshav qab zib (recombinant route), hnyav poob / mob ntshav qab zib ntau ntau thiab ua ntej sau cwj mem 5ml: 0.25mg, cas no.: 910463-68-2 manufacturers, lwm tus neeg, Hoobkas